Ozempic and Wegovy both contain semaglutide — but they are not the same drug and are not interchangeable. Ozempic is approved for type 2 diabetes at up to 2mg weekly (7–10% weight loss). Wegovy is approved for obesity at up to 2.4mg weekly (15% weight loss) — and the new Wegovy HD at 7.2mg (approved March 2026) pushes that to 20%+. This complete 2026 comparison covers every difference: FDA indications, dose titration charts, weight loss outcomes, new oral forms.