Ozempic and Wegovy are the same drug at different doses. SURMOUNT-5 confirmed tirzepatide produces 47% more weight loss than semaglutide. This 2026 complete guide covers the GLP-1 vs dual GIP mechanism, Ozempic vs Wegovy explained, tirzepatide 21% weight loss data, why two-thirds of weight returns after stopping, nausea tips, MTC black box warning, and semaglutide now $150/month after Novo Nordisk's 70% price cut.

Ozempic and Wegovy both contain semaglutide — but they are not the same drug and are not interchangeable. Ozempic is approved for type 2 diabetes at up to 2mg weekly (7–10% weight loss). Wegovy is approved for obesity at up to 2.4mg weekly (15% weight loss) — and the new Wegovy HD at 7.2mg (approved March 2026) pushes that to 20%+. This complete 2026 comparison covers every difference: FDA indications, dose titration charts, weight loss outcomes, new oral forms.

Ozempic (semaglutide) is America's most searched drug — and in 2026 the landscape has changed dramatically. The 3-year shortage is officially over. Oral semaglutide tablets are now FDA-approved. Wegovy HD (7.2mg) has launched. And compounded semaglutide has been shut down by the FDA.