Acne affects 50 million Americans — but it is one of the most treatable skin conditions when matched to the right treatment. This dermatologist-backed guide covers every option from OTC benzoyl peroxide and adapalene to prescription doxycycline, spironolactone, and isotretinoin — with a clear table matching treatment to your specific acne type.

Doxycycline is the AAD's first-line oral antibiotic for moderate to severe acne — and clinical studies show 50–70% reduction in inflammatory lesions at 12 weeks, with 78% of patients achieving cure or significant improvement. But the correct dose, the 3-month duration rule, and the photosensitivity warning that most prescribers forget to mention make all the difference. This complete 2026 guide covers exact dosage by severity, the week-by-week results timeline.