Telmisartan has the longest half-life of all ARBs (24 hours) for true round-the-clock blood pressure control. This 2026 guide covers the ONTARGET trial (25,620 patients), 40mg vs 80mg dosing, the unique PPAR-gamma metabolic benefit shared by no other ARB, the potassium monitoring warning, a 5-ARB comparison table, and why telmisartan outperforms losartan in the early morning blood pressure surge.