Sertraline is the USA's most prescribed SSRI — 42.5M Rx/yr and 6 FDA indications. This 2026 complete guide covers why it takes 4–8 weeks (neuroplasticity explained), which side effects resolve vs which persist, MAOI serotonin syndrome black box, the under-25 suicidal ideation warning in full context, PMDD luteal-phase dosing, discontinuation brain zaps, and sertraline vs escitalopram vs bupropion comparison table.