Enclomiphene raises testosterone through the body's own HPT axis while preserving sperm — unlike TRT which suppresses both. This 2026 guide covers the Phase III trial evidence (+274 ng/dL in 10-RCT meta-analysis), the HPT axis mechanism, full enclomiphene vs TRT vs clomiphene comparison table, FDA regulatory status (not approved — May 2026), side effects, and who it is and is not appropriate for.