Ozempic and Wegovy are the same drug at different doses. SURMOUNT-5 confirmed tirzepatide produces 47% more weight loss than semaglutide. This 2026 complete guide covers the GLP-1 vs dual GIP mechanism, Ozempic vs Wegovy explained, tirzepatide 21% weight loss data, why two-thirds of weight returns after stopping, nausea tips, MTC black box warning, and semaglutide now $150/month after Novo Nordisk's 70% price cut.