1.2 million Americans have HIV — 13% undiagnosed. This 2026 guide covers how ART works across 5 drug classes, Jan 2026 NYSDOH preferred regimens, the Aug 27 2026 FDA-approved Bixlenvo, why U=U means undetectable people cannot sexually transmit HIV, PrEP vs PEP injection, a full monitoring table, and what cure research looks like in 2026.